Thermo Fisher Scientific TGF-alpha Polyclonal Antibody
Human TGF-alpha 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC와 ELISA에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 완충액에 안정화제가 포함되어 있습니다. 세포막 및 분비 위치에서 발현되는 TGF-alpha 검출에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of human TGF-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human liver and hepatocellular carcinoma tissues
- Cellular location: Cell membrane and Secreted
Target Information
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor and stimulates the proliferation of various epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and tumor cells. TGF-alpha induces anchorage-independent transformation in cultured cells. Human, murine, and rat TGF-alpha are cross-species reactive. TGF-alpha (aa 50) has 33% homology to EGF, binds to EGFR, activates receptor tyrosine phosphorylation, and promotes cell proliferation. It plays a role in tumor initiation by inducing a reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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