Thermo Fisher Scientific SOX17 Recombinant Rabbit Monoclonal Antibody (6H42L1)
인간 SOX17 단백질을 인식하는 재조합 토끼 단클론 항체. ICC/IF에 적합하며 높은 특이성과 민감도 제공. 단백질 A 정제, PBS 완충액에 0.09% sodium azide 포함. 4°C 단기 보관, 장기 보관은 -20°C 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6H42L1 |
| Immunogen | Protein corresponding to human Sox17 [aa177–aa414] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784556 |
Product Specific Information
- This antibody is predicted to react with Monkey, Cat, and Bovine.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
- The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
- Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMG box family of transcription factors.
It acts as a transcription regulator that binds and bends target promoter DNA sequences (5'-AACAAT-3' or 5'-AACAAAG-3').
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling by promoting degradation of activated CTNNB1.
It plays an essential role in embryonic development, particularly in heart tube looping and definitive gut endoderm formation.
Mutations in SOX17 can result in vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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