Thermo Fisher Scientific SOX17 Recombinant Rabbit Monoclonal Antibody (6H42L1)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

• This antibody is predicted to react with Monkey, Cat, and Bovine.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
• The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

1. Better specificity and sensitivity
2. Lot-to-lot consistency
3. Animal origin-free formulations
4. Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

SOX17 (transcription factor SOX-17) belongs to the SRY-related HMG box family of transcription factors.
It acts as a transcription regulator that binds and bends target promoter DNA sequences (5'-AACAAT-3' or 5'-AACAAAG-3').
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling by promoting degradation of activated CTNNB1.
It plays an essential role in embryonic development, particularly in heart tube looping and definitive gut endoderm formation.
Mutations in SOX17 can result in vesicoureteral reflux.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.