Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (5H29L5)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, Pig, and Sheep.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broad immunoreactivity due to larger rabbit immune repertoire

Target Information

SATB2 is a DNA-binding protein that associates with nuclear matrix/scaffold regions. It recognizes double-stranded DNA structure and functions as a transcription factor regulating nuclear gene expression through chromatin-loop remodeling.
It recruits chromatin remodeling enzymes such as HDACs and HATs to promoters and enhancers. SATB2 is essential for initiation of upper-layer neuron-specific gene programs and repression of deep-layer genes, influencing corticocortical connections in the developing cerebral cortex.
Mutations in SATB2 are associated with cleft palate isolated (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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