Thermo Fisher Scientific pS2/pNR-2/TFF1 (Estrogen-Regulated Protein) Recombinant Rabbit Monoclonal Antibody (TFF1, 2969R)

Thermo Fisher Scientific pS2/pNR-2/TFF1 (Estrogen-Regulated Protein) Recombinant Rabbit Monoclonal Antibody (TFF1, 2969R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL
Publications: [References not provided]

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at room temperature for 20 min before staining.

Target Information

Members of the trefoil family possess at least one trefoil motif, a 40-amino acid domain with three conserved disulfide bonds. These stable secretory proteins are expressed in gastrointestinal mucosa and may:

• Protect mucosa from insults
• Stabilize the mucus layer
• Promote epithelial healing

The TFF1 gene, expressed in the gastric mucosa, is also associated with human tumors. It forms a gene cluster on chromosome 21 along with two related trefoil family genes.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.

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