Thermo Fisher Scientific PKR Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced during viral infection. PKR is involved in IFN-induced innate antiviral responses, virus-induced apoptosis, and regulation of cell growth and differentiation. It induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling. Upon viral infection, PKR functions as a dual protein, sequentially activating both cell survival and cell death pathways using kinase-independent and dependent mechanisms. PKR regulates multiple pathways including NF-kappaB activation, p53, p38, and PDGF signaling. It is implicated in tumor suppression and malignancy. Viruses have evolved mechanisms to evade PKR’s antiviral effects, such as inhibition by influenza virus NS1 protein. PKR has also been implicated in neurodegenerative diseases including Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.