Thermo Fisher Scientific SIRT1 Polyclonal Antibody
SIRT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB와 ICC/IF에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the carboxy terminus of human SirT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 18 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10999947 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other sirtuin proteins.
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 can modulate chromatin function through deacetylation of histones and promote alterations in the methylation of histone and DNA, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and, in response to low nutrients, mediates the inhibitory effect on skeletal myoblast differentiation involving 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-17393_SIRT1_Q96EB6-1_Rabbit.svg
- PA5-17393_SIRT1_Q96EB6-1_Rabbit_PDP.jpeg
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