Thermo Fisher Scientific Phospho-C/EBP alpha (Thr230) Polyclonal Antibody
C/EBPα 단백질의 Thr230 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며, 인간 시료에 반응합니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Suggested positive control: COS7 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 230 (P-P-T(p)-P-V) derived from Human C/EBP-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554130 |
Target Information
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors—alpha, beta, delta, and epsilon—are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L)KXEP.
One of the major roles of these transcription factors is metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of adipose cells.
Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different functions in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in Alzheimer’s disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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