Thermo Fisher Scientific Phospho-Cofilin (Tyr139) Polyclonal Antibody
Phospho-Cofilin (Tyr139) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응. IHC(P)에서 1:50~1:100 희석으로 사용 가능. 액상 형태이며 1 mg/mL 농도, PBS/glycerol 버퍼에 보관. 세포골격 조절 연구에 적합한 연구용 항체.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 139 (N-C-Y(p)-E-E) derived from Human cofilin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554132 |
Product Specific Information
A suggested positive control for IHC is human lung carcinoma.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity.
Regulates actin cytoskeleton dynamics and is important for normal progress through mitosis and cytokinesis.
Plays a role in the regulation of cell morphology and cytoskeletal organization.
Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartments to the cell membrane, enhancing chemokine uptake and degradation.
Essential for neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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