Thermo Fisher Scientific CTCF Polyclonal Antibody
CTCF 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 인간에 반응합니다. 액상 형태로 제공되며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 150 and 200 of human CCCTC-binding factor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat
Target Information
Transcriptional factor CTCF is a ubiquitously expressed, 11-zinc finger domain-containing DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and imprinting control.
CTCF interacts with CCCTC motifs on DNA and can bind to HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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