Thermo Fisher Scientific p400 Polyclonal Antibody
Thermo Fisher Scientific의 p400 폴리클로날 항체로, 인간 및 마우스 반응성. Western blot과 IP에 적합하며, 항원 친화 크로마토그래피로 정제됨. NuA4 히스톤 아세틸트랜스퍼라아제 복합체 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 3075 and the C-terminus (residue 3124) of human E1A binding protein p400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Rat, Bovine, Horse, Guinea pig_10141, Pig, Orangutan, Monkey, Gorilla, and Chimpanzee
Target Information
Component of the NuA4 histone acetyltransferase complex, involved in transcriptional activation of select genes by acetylation of nucleosomal histones H4 and H2A.
This modification may alter nucleosome-DNA interactions and promote interaction with other proteins regulating transcription.
May be required for activation of E2F1 and MYC target genes during cellular proliferation.
The NuA4 complex ATPase and helicase activities are partly contributed by the association of RUVBL1 and RUVBL2 with EP400.
May regulate ZNF42 transcription activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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