Thermo Fisher Scientific GR Polyclonal Antibody
Glucocorticoid Receptor 인식 Rabbit Polyclonal Antibody로 Western Blot, IHC, IP 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 액상형 비결합 항체. 인간 및 오랑우탄 반응성, 안정적 보관 및 높은 특이성 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Glucocorticoid Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that acts as both a transcription factor and a regulator of other transcription factors. It can form heteromeric cytoplasmic complexes with heat shock factors and immunophilins. Upon ligand binding, the receptor translocates into the nucleus. It is expressed in the heart, including left and right atria, ventricles, aorta, apex, septum, and atrioventricular node, as well as in adult and fetal heart tissues.
Alternate splicing and promoter usage result in multiple transcript variants or isoforms. Mutations in the gene can lead to glucocorticoid resistance (cortisol resistance). GR must associate with chaperone protein complexes for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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