Thermo Fisher Scientific Human M-CSF, Animal-Free Recombinant Protein, PeproTech
Animal-free recombinant human M-CSF protein for research use. Highly purified (≥98%) with low endotoxin (<0.1 EU/µg). Promotes monocyte and macrophage proliferation. Expressed in E. coli and supplied lyophilized for stable storage at -20°C.
- 카탈로그번호
- AF-300-25-xxxxx (3개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human M-CSF, Animal-Free Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (63 available)
Miscellaneous PubMed (Misc)
- Refer to publications (3 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS |
| Molecular Weight | 36.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | ED50 ≤ 1.0 ng/ml (specific activity ≥ 1 × 10⁶ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells.
It also induces VEGF secretion by macrophages, promoting endothelial progenitor cell mobilization and neovascularization.
M-CSF exists in multiple bioactive isoforms differing in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or cleaved and modified in secretory vesicles.
It forms a disulfide-bonded homodimer processed into glycoprotein or proteoglycan isoforms, modified by chondroitin sulfate addition.
Binding of M-CSF to its receptor c-Fms (CSF-1R/CD115) induces receptor dimerization, internalization, and degradation. Functionally, M-CSF stimulates differentiation of hematopoietic stem cells to monocyte-macrophage populations in culture.
Human M-CSF shows activity on mouse cells, whereas mouse CSF shows no activity on human cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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