Thermo Fisher Scientific Human Leptin, Animal-Free Recombinant Protein, PeproTech

Applications

• Functional Assay (Assay-dependent)

Product Specifications

Product Specific Information

Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

Target Information

Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism, and reproductive function. It is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is mainly expressed by adipocytes, correlating with total body fat mass. Smaller amounts are secreted by stomach epithelium and placenta cells.
Leptin receptors are highly expressed in hypothalamic regions regulating body weight, and also found in T lymphocytes and vascular endothelial cells.
Leptin influences feeding behavior, hunger, body temperature, and energy expenditure through hypothalamic receptors. It promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, pubertal development, and fetal growth.
Research has linked leptin to obesity, anorexia nervosa, insulin resistance, and hypertension. It also has thermogenic actions and regulates fatty acid oxidation enzymes. Defects in leptin production can cause severe hereditary obesity in rodents and humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.