Thermo Fisher Scientific SMO Polyclonal Antibody
SMO 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 Human, Mouse, Rat에서 반응. 항원 친화 크로마토그래피로 정제된 액상형 제품으로 안정적 보관 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region 85–116 aa of SMO (UniProt ID: Q99835-1, antigen length 787 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2718249 |
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It contains seven transmembrane domains, four glycosylation sites, and a putative extracellular amino terminus. Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Sonic hedgehog (Shh) and positively regulates the hedgehog signaling pathway along with the inhibitor patched protein (PTCH). This pathway controls vertebrate development, cellular proliferation, and differentiation by activating transcription factor Gli. Mutations in Smoothened are associated with sporadic basal cell carcinoma of the skin and it is widely expressed in the heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-72395_SMO_Q99835-1_Rabbit_PDP.jpeg)
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