Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간 및 설치류 등 여러 종에 반응하며, 항원 친화 정제 방식으로 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rodent, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Tyrosine Hydroxylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792498 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (92%), Rat (93%), Zebrafish (82%), Japanese Medaka (83%), Xenopus laevis (83%), Dog (96%), Chicken (88%), Bovine (93%).
- Positive Control: NT2D1, PC-3, U87-MG, SK-N-SH, mouse brain, PC-12, rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1–hTH4) have been isolated. These variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa and plays a key role in the physiology of adrenergic neurons. Dysregulation of TH is associated with neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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