Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (92%), Rat (93%), Zebrafish (82%), Japanese Medaka (83%), Xenopus laevis (83%), Dog (96%), Chicken (88%), Bovine (93%).
• Positive Control: NT2D1, PC-3, U87-MG, SK-N-SH, mouse brain, PC-12, rat brain.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1–hTH4) have been isolated. These variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa and plays a key role in the physiology of adrenergic neurons. Dysregulation of TH is associated with neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.