Thermo Fisher Scientific TNFAIP3 Polyclonal Antibody
TNFAIP3(A20) 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot에 적합하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관하며 장기 저장 시 -20°C에서 유지합니다.
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Applications
Tested Dilution
- Western Blot (WB): 1:5,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human A20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792499 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (83%), Pig (81%), Rhesus Monkey (97%).
- Positive Control: 3xFlag-human TNFAIP3-transfected 293T.
- Centrifuge briefly prior to opening the vial.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It acts as a tumor suppressor gene in Hodgkin lymphoma and several non-Hodgkin lymphoma subtypes. TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. It also negatively regulates TLR-mediated inflammatory responses, preventing excessive immune reactions. At least two isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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