Thermo Fisher Scientific SIGLEC7 Monoclonal Antibody (OTI1E3), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

SIGLEC7 is a putative adhesion molecule that mediates sialic acid-dependent binding to cells, preferentially binding alpha-2,3- and alpha-2,6-linked sialic acids. It also binds disialogangliosides and may have its recognition site masked by cis interactions on the same cell surface.
In immune responses, SIGLEC7 acts as an inhibitory receptor by recruiting cytoplasmic phosphatases that block signal transduction via dephosphorylation. It mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis, inhibiting differentiation of CD34+ precursors toward the myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.