Thermo Fisher Scientific SIGLEC7 Monoclonal Antibody (OTI1A12), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

SIGLEC7 is a putative adhesion molecule mediating sialic acid-dependent binding to cells. It preferentially binds alpha-2,3- and alpha-2,6-linked sialic acids and disialogangliosides.
Its sialic acid recognition site may be masked by cis interactions on the same cell surface.
In immune responses, SIGLEC7 may act as an inhibitory receptor by recruiting cytoplasmic phosphatases via SH2 domains, blocking signal transduction through dephosphorylation.
It mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis by inhibiting differentiation of CD34+ precursors toward myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.