Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Nurr1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용 가능. 인간 및 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100–1:200 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide comprising residues 513–526 of the human Nurr1 protein. Based on 100% sequence homology, this antibody is also expected to cross-react with rat and mouse Nurr1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153541 |
Product Specific Information
Suggested positive control: antigen standard for NR4A2 (transient overexpression lysate).
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been linked to disorders involving dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation may also be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, with additional potential splice variants not yet fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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