Thermo Fisher Scientific CSK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

CSK is a tyrosine kinase that downregulates SRC oncoprotein activity through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by mechanisms interfering with this phosphorylation, the CSK gene may function as an antioncogene. CSK regulates cell growth, differentiation, migration, and immune responses. It phosphorylates tyrosine residues in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is ubiquitously expressed as a ~50 kDa cytosolic protein, with a fraction localized to lipid rafts via interaction with PAG (Csk-binding protein).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.