Thermo Fisher Scientific TG2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt

Target Information

Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity.
In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity is associated with polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, leading to neurofibrillary tangle formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.