Thermo Fisher Scientific TG2 Polyclonal Antibody
Human TG2 단백질을 인식하는 Rabbit 폴리클로날 항체로 Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 4°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 to 600 of Human Transglutaminase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity.
In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity is associated with polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, leading to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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