Thermo Fisher Scientific Phospho-MEKK1 (Thr1402) Polyclonal Antibody
Phospho-MEKK1 (Thr1402) 특이적 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. Rabbit IgG 기반의 비결합형 액상 항체로 1 mg/mL 농도 제공. MAPK 신호전달 연구용으로 적합하며, -20°C 보관 및 Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MEKK1 around the phosphorylation site of Thr1402. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903396 |
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. These kinases are highly conserved across species, including yeast, Drosophila, and mammals.
MEKK1 can phosphorylate and activate MAPKK1 and MAPKK2 (MEK1/MEK2), leading to phosphorylation of MAP kinases. It is also a potent activator of the JNK cascade. The protein contains a putative RING-type zinc finger and a SWIM-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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