Thermo Fisher Scientific SCNN1B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
• Predicted reactivity: Dog (82%), Guinea pig (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and also contributes to taste perception.
Composed of two alpha, one beta, and one gamma subunit; a delta subunit can replace alpha. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease due to organ unresponsiveness to mineralocorticoids. PHA1 presents in neonates with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, and failure to thrive.
Defects in SCNN1B also cause Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis, due to constitutive activation of the renal epithelial sodium channel.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.