Thermo Fisher Scientific Phospho-KIF1B (Ser1487) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of KIF1B only when phosphorylated at Ser1487.

Target Information

The kinesins constitute a large family of microtubule-dependent motor proteins responsible for the distribution of numerous organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in:

• Cell division
• Intracellular transport
• Membrane trafficking events including endocytosis and transcytosis

KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins involved in the transport of mitochondria or synaptic vesicles in axons.
It is an amino-terminal-type motor protein ubiquitously expressed, with the highest levels in differentiated nerve cells.
The human KIF1B gene maps to chromosome 1p36.2.
Defects in axonal transport due to mutations in the KIF1B gene can underlie peripheral neuropathy phenotypes.
The mouse KIF1B gene produces two isoforms through alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.