Thermo Fisher Scientific Phospho-KSR1 (Ser392) Polyclonal Antibody
KSR1 단백질의 Ser392 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western Blot 및 IHC(P) 적용 가능. Human과 Mouse 시료 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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- PA5104607
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from mouse KSR1 (Accession Q61097), corresponding to amino acid residues around phosphorylated Ser392. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816082 |
Product Specific Information
This antibody detects endogenous levels of KSR1 only when phosphorylated at Ser460, which site was historically referenced as Ser392.
Target Information
KSR1 is part of a multiprotein signaling complex that promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, it acts as a MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF. Upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, it dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). It promotes activation of MAPK1 and/or MAPK3 in response to EGF and cAMP. Its kinase activity remains uncertain; although some protein kinase activity has been detected in vitro, its physiological relevance is unknown. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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