Thermo Fisher Scientific LIMP2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Despite its predicted molecular weight, LIMP2 often migrates at 80–85 kDa in SDS-PAGE.
A suggested positive control is human skeletal muscle tissue lysate.
PA5-20544 can be used with blocking peptide PEP-0664.

Target Information

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different.
SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
SR-BII is abundant in mouse tissues expressing SR-BI, with expression in liver, adrenal glands, and testes.
Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor.
SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts, and the SR-BII isoform mediates selective transfer of lipid between HDL and cells.
The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.