Thermo Fisher Scientific CLIP1 Polyclonal Antibody
CLIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체로, 2–8°C 보관 권장. 연구용 전용 제품.
- 카탈로그번호
- PA520545
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human CLIP170 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154603 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20545 can be used with blocking peptide PEP-0665
Target Information
CLIP170 was initially identified as a new type of intermediate filament-associated protein highly expressed in Reed-Sternberg cells, which are diagnostic for Hodgkin’s disease. It is located at microtubule plus ends and required for the binding of endocytic carrier vesicles. CLIP170 acts with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding to microtubules. Studies suggest CLIP170 influences lamellipodia formation and cell invasion in breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex involving CLIP170 and Rac1. At least two isoforms of CLIP170 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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