Thermo Fisher Scientific uPAR Recombinant Mouse Monoclonal Antibody (2E2)
Thermo Fisher Scientific의 uPAR Recombinant Mouse Monoclonal Antibody (2E2)는 인간 PLAUR 단백질을 인식하는 재조합 단일클론 항체입니다. ICC/IF, Flow Cytometry, ELISA에 적합하며, 높은 특이성과 재현성을 제공합니다. 연구용으로 세포막 단백질 분석 및 암 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
| Flow Cytometry (Flow) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2E2 |
| Immunogen | Recombinant Human PLAUR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092458 |
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes. The human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) in monocytes, anchored to the plasma membrane by a glycosyl-phosphatidylinositol linkage.
PLAUR (also known as uPAR) interacts with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent. uPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced clinical stages compared with normal tissue. Increased uPAR expression correlates linearly with disease progression, recurrence rate, and mortality in endometrial cancer patients, making uPAR a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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