Thermo Fisher Scientific CD273 (B7-DC) Monoclonal Antibody (7F11D11)

Applications and Tested Dilutions

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for PD-1. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma.

Although PD-L2 is generally expressed at lower levels than PD-L1, it has a 2–6 times higher affinity for PD-1. PD-1 and its ligands function as inhibitory immune checkpoint molecules, providing negative feedback during immune homeostasis. Binding of PD-L2 or PD-L1 to PD-1 inhibits T cell activation, proliferation, and cytokine secretion (e.g., IFN-gamma, IL-10), thereby dampening immune responses.

PD-L2 can also stimulate T cell proliferation and cytokine production independently of PD-1, suggesting additional receptors. Recent studies have shown that PD-L2 binds to repulsive guidance molecule b (RGMb), which regulates respiratory tolerance in the lung through BMP and/or neogenin signaling pathways. The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.