Thermo Fisher Scientific c-Abl Recombinant Rabbit Monoclonal Antibody (4Y8V9)
Thermo Fisher Scientific의 c-Abl Recombinant Rabbit Monoclonal Antibody (4Y8V9)는 마우스 및 랫트 조직에서 c-Abl 단백질 검출에 적합합니다. HEK293 세포에서 발현된 재조합 단클론 항체로, 높은 특이성과 재현성을 제공합니다. IHC와 ELISA에 최적화되어 있으며, 안정적인 액상 형태로 -20°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4Y8V9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1000–1130 of human c-Abl (NP_005148.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.076 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3092437 |
Product Specific Information
Immunogen sequence:
TAFIPLISTR VSLRKTRQPP ERIASGAITK GVVLDSTEAL CLAISRNSEQ MASHSAVLEA GKNLYTFCVS YVDSIQQMRN KFAFREAINK LENNLRELQI CPATAGSGPA ATQDFSKLLS SVKEISDIVQ R
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl protein is negatively regulated by its SH3 domain; deletion of this domain turns c-Abl into an oncogene.
In chronic myelogenous leukemia and certain acute lymphoblastic leukemias, the c-Abl gene undergoes a (9;22) translocation forming the Philadelphia chromosome, resulting in fusion with the Bcr gene.
The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating the proapoptotic pathway when DNA damage is irreparable.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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