Thermo Fisher Scientific c-Abl Recombinant Rabbit Monoclonal Antibody (4Y8V9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:

TAFIPLISTR VSLRKTRQPP ERIASGAITK GVVLDSTEAL CLAISRNSEQ MASHSAVLEA GKNLYTFCVS YVDSIQQMRN KFAFREAINK LENNLRELQI CPATAGSGPA ATQDFSKLLS SVKEISDIVQ R

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl protein is negatively regulated by its SH3 domain; deletion of this domain turns c-Abl into an oncogene.
In chronic myelogenous leukemia and certain acute lymphoblastic leukemias, the c-Abl gene undergoes a (9;22) translocation forming the Philadelphia chromosome, resulting in fusion with the Bcr gene.
The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating the proapoptotic pathway when DNA damage is irreparable.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.