Thermo Fisher Scientific CHI3L1 Recombinant Rabbit Monoclonal Antibody (7T1R3)
Recombinant rabbit monoclonal antibody (clone 7T1R3) specific for CHI3L1/YKL-40, validated for WB, ICC/IF, and ELISA. High purity (1 mg/mL) from HEK293 expression system. Suitable for human and mouse samples. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7T1R3 |
| Immunogen | A synthetic peptide corresponding to amino acids 284–383 of human YKL-40/CHI3L1 (NP_001267.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093757 |
Product Specific Information
Immunogen sequence:
PGRFTKEAGT LAYYEICDFL RGATVHRILG QQVPYATKGN QWVGYDDQES VKSKVQYLKD RQLAGAMVWA LDLDDFQGSF CGQDLRFPLT NAIKDALAAT
Target Information
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes, and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells, and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and plays a role in cellular response to environmental changes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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