Thermo Fisher Scientific PRRX1 Monoclonal Antibody (OTI1F8), TrueMAB
PRRX1 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. Human 시료에 반응하며, Affinity chromatography로 정제됨. PBS, BSA, glycerol 기반 완충액에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F8 |
| Immunogen | Full length human recombinant protein of human PRRX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species and functions to bind DNA via a helix-turn-helix structure, playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to the establishment of mesodermal muscle types.
PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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