Thermo Fisher Scientific IL1F6 Polyclonal Antibody
Thermo Fisher Scientific IL1F6 Polyclonal Antibody는 mouse IL-36α/IL-1F6 단백질을 인식하는 goat 유래 polyclonal 항체로, Western blot과 neutralization assay에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose buffer에 동결건조 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Neutralization (Neu) | 40 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse IL-36 alpha/IL-1F6 (Met1–His160) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577138 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human IL-1F5, IL-1F6, and IL-1F9 is observed.
- Less than 2% cross-reactivity with recombinant mouse IL-1F8, human IL-1F7, IL-1α, IL-1β, IL-1ra, and IL-18.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
The IL-1 family consists of 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and uniquely expressed by T cells, monocytes, and B cells.
It is primarily found in skin and lymphoid tissues and to a lesser extent in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, acting as an agonist of NF-κB and MAPK pathways.
It induces production of proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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