Thermo Fisher Scientific IL36B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Neutralization (Neu)

Assay-Dependent

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived recombinant mouse IL-36 beta/IL-1F8 Met1-Lys183 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL36B,uniProtId:Q9D6Z6-1,ncbiNodeId:10090,antigenRange:1-183,antigenLength:183,antigenImageFileName:PA5-47294_IL36B_Q9D6Z6-1_Goat.svg,antigenImageFileNamePDP:PA5-47294_IL36B_Q9D6Z6-1_Goat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2605585

Product Specific Information

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1F8 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IL-1 alpha, rmIL-1 beta, rmIL-1ra, rmIL-18, rhIL-1F5, rmIL-1F6, rhIL-1F7, rhIL-1F9 and rhIL-1F10 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.