Thermo Fisher Scientific IL36B Polyclonal Antibody
Mouse IL-36β(IL-1F8)에 특이적인 Goat Polyclonal Antibody. Western blot 및 Neutralization assay에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 보존제 무첨가. -20°C에서 보관하며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse IL-36 beta / IL-1F8 (Met1–Lys183) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605585 |
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1F8 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IL-1α, rmIL-1β, rmIL-1ra, rmIL-18, rhIL-1F5, rmIL-1F6, rhIL-1F7, rhIL-1F9, and rhIL-1F10 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
IL-36B is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-κB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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