Thermo Fisher Scientific IL36B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1F8 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IL-1α, rmIL-1β, rmIL-1ra, rmIL-18, rhIL-1F5, rmIL-1F6, rhIL-1F7, rhIL-1F9, and rhIL-1F10 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

IL-36B is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-κB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.