Thermo Fisher Scientific 4-1BB Ligand Polyclonal Antibody
Human 4-1BB Ligand을 인식하는 Goat Polyclonal Antibody로, WB, IHC, Flow Cytometry에 사용 가능. E. coli 유래 재조합 항원으로 면역. 높은 특이성과 낮은 교차반응. 연구용으로만 사용.
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Thermo Fisher Scientific 4-1BB Ligand Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–15 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human 4-1BB Ligand/TNFSF9 (Arg71–Glu254) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608811 |
Product Specific Information
In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse 4-1BB Ligand, recombinant human APRIL, BAFF, EDA-A2, Fas Ligand, GITR Ligand, LIGHT, OX40 Ligand, TNF-alpha, TRAIL, and TWEAK is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is expressed on various cells, including inflamed endothelial cells, where interaction enhances monocyte extravasation.
Activated T cells express CD137, and engagement with CD137L promotes T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is also found on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but absent in Hodgkin and T-cell lymphomas.
It is expressed in carcinoma cell lines and may play a role in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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