Thermo Fisher Scientific TLR5 Polyclonal Antibody
TLR5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 사용 가능. 인간과 생쥐 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 세포 내 TLR5 신호 연구에 적합.
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Thermo Fisher Scientific TLR5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152531 |
Product Specific Information
- Suggested positive control: THP-1 cell lysate
- Can be used with blocking peptide PEP-0316
- Avoid exposure to prolonged high temperatures
Target Information
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participating in the innate immune response to microbial agents. It plays a role in detecting bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion, and inflammatory responses.
TLR5 is highly expressed in the liver, detected in the lung, and at low levels in most other tissues. The TLR5 gene locus is associated with susceptibility to Salmonella. Mouse strains exhibit varying resistance to S. typhimurium infection depending on their TLR5 haplotype.
A common TLR5 stop codon polymorphism disrupting TLR5 signaling is linked to susceptibility to Legionnaires' disease, highlighting its importance in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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