Thermo Fisher Scientific TLR5 Polyclonal Antibody
TLR5 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 용액 형태로 제공되며 2–8°C에서 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 16 amino acids near the center of human TLR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152032 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20185 can be used with blocking peptide PEP-0315
Target Information
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and inflammatory responses.
TLR5 is highly expressed in liver, detected in lung, and present at low levels in most other tissues. The TLR5 gene locus is associated with susceptibility to Salmonella. Mouse strains vary in resistance to S. typhimurium infection, classified as susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L), or resistant (A, CBA). The MOLF/Ei strain shows high susceptibility, a unique TLR5 haplotype, and lower TLR5 expression.
A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is linked to susceptibility to Legionnaires’ disease, underscoring its role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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