Thermo Fisher Scientific FOXO4 Recombinant Rabbit Monoclonal Antibody (SD0817)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. Also known as AFX1 or MLLT7, it is a member of the O class of forkhead/winged helix transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of Akt, another downstream target of the Insulin/IGF1 pathway, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, promoting its interaction with 14-3-3 proteins and translocation out of the nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.