Thermo Fisher Scientific FOXO4 Recombinant Rabbit Monoclonal Antibody (SD0817)
FOXO4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 높은 특이성과 재현성을 제공하며, 로트 간 일관성을 보장합니다. 단백질 A로 정제되어 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD0817 |
| Immunogen | Synthetic peptide within Human FOXO4 aa 178–227 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809665 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. Also known as AFX1 or MLLT7, it is a member of the O class of forkhead/winged helix transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of Akt, another downstream target of the Insulin/IGF1 pathway, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, promoting its interaction with 14-3-3 proteins and translocation out of the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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