Thermo Fisher Scientific TSC1 Polyclonal Antibody
TSC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot과 IHC(Paraffin) 실험에 적합합니다. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Hamartin/TSC1. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.38 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2736754 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS
- Predicted Reactivity: Rat (80%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases signaling of the mammalian Target of Rapamycin (TOR), a serine/threonine kinase regulating cell growth and the cell cycle.
TOR activity is stimulated by Rheb, a Ras superfamily G-protein, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity, suggesting that TSC1/TSC2 decreases Rheb-mediated TOR activation. Overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been identified, though its function remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-78208_TSC1_Q92574-1_Rabbit.svg, PA5-78208_TSC1_Q92574-1_Rabbit_PDP.jpeg)
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