Thermo Fisher Scientific Troponin I Polyclonal Antibody
Human Troponin I를 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol buffer에 보관됩니다. 다양한 종에서 높은 예측 반응성을 보이며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TNNI1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.36 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2736715 |
Product Specific Information
- Positive Control: Raji
- Predicted Reactivity: Mouse (98%), Rat (97%), Pig (98%), Rhesus Monkey (100%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles.
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), forms the troponin complex of thin filaments in striated muscle.
TnI acts as the inhibitory subunit, blocking actin-myosin interactions and mediating muscle relaxation.
The TnI subfamily includes three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac.
This gene encodes the Troponin-I-skeletal-slow-twitch protein, expressed in cardiac and skeletal muscle during early development and restricted to slow-twitch skeletal muscle fibers in adults.
The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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