Thermo Fisher Scientific Troponin I Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Positive Control: Raji
• Predicted Reactivity: Mouse (98%), Rat (97%), Pig (98%), Rhesus Monkey (100%), Bovine (97%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles.
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), forms the troponin complex of thin filaments in striated muscle.
TnI acts as the inhibitory subunit, blocking actin-myosin interactions and mediating muscle relaxation.
The TnI subfamily includes three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac.
This gene encodes the Troponin-I-skeletal-slow-twitch protein, expressed in cardiac and skeletal muscle during early development and restricted to slow-twitch skeletal muscle fibers in adults.
The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.