Thermo Fisher Scientific Blood Group ABH Antigen Monoclonal Antibody (HE-10)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody reacts with A and H antigens with chain types 3 and 4 and does not react with A disaccharide, A trisaccharide, A type 1, A type 2, ALe-b.
The antibody HE-10 does not react with normal tissue sections of donors with blood group B and O, but it reacts specifically with malignant tissue.

Target Information

Blood-group antigens are molecules formed by sequential addition of saccharides to carbohydrate side chains of lipids and proteins found on erythrocytes and certain epithelial cells.
The A, B, and H antigens undergo modulation during malignant cellular transformation.
Blood group-related antigens represent carbohydrate determinants carried on both glycolipids and glycoproteins, typically mucin-type, detected on erythrocytes, epithelial cells, and in secretions of certain individuals.
Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.