Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI2B11)
인간 CD137(TNFRSF9)을 인식하는 Mouse IgG2a 단일클론 항체로, Flow Cytometry에 최적화되어 있습니다. HEK293T 세포에서 발현된 재조합 단백질로 면역화되었으며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B11 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling maintains the survival of activated T cells and CD8+ memory T cells, promotes clonal expansion of T cells, and suppresses myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide a negative control mechanism for certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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