Thermo Fisher Scientific TCR V beta 9 Monoclonal Antibody (AMKB1-2), PE, eBioscience

Thermo Fisher Scientific TCR V beta 9 Monoclonal Antibody (AMKB1-2), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution

• 5 µL (0.125 µg)/test

Publications

• View 2 publications

Product Specifications

Additional Formats

• APC
• Request custom conjugation

Product Specific Information

This AMKB1-2 monoclonal antibody recognizes the human T cell receptor (TCR) Vβ9 allele.
TCR specificity is determined by Valpha, Jalpha, Vbeta, Dbeta, and Jbeta gene rearrangement.
Vβ expression has been studied in relation to superantigens, inflammation, autoimmune disease, and HIV infection.
It is used to phenotype T cell clonality in CD3⁺/TCRαβ⁺ large granular lymphocyte leukemias.
This receptor, a member of the Ig superfamily, is expressed on a subset of peripheral blood T cells.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated for flow cytometry on normal human peripheral blood cells.
Use at 5 µL (0.125 µg) per test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

T cell receptors (TCRs) discriminate foreign from self-peptides presented by MHC class II molecules, critical for adaptive immune responses.
Self-peptide recognition is linked to autoimmune disease, while mutant self-peptides are associated with tumors.
Superantigen engagement of TCRs can cause toxic shock syndrome.
Autoantibodies to Vβ segments have been found in RA and SLE patients, potentially modulating TH1-mediated inflammation.
Most human T cells express TCR αβ and either CD4 or CD8; a small subset lacks both (double negative).
Gamma-delta T cells, found mainly in epithelia, show limited diversity and distinct antigen recognition, with antitumor and immunoregulatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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