Thermo Fisher Scientific FANCD2 Polyclonal Antibody, HRP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000-1:20,000

-

Immunohistochemistry (Paraffin) (IHC (P))

2.5-5 µg/mL

-

Product Specifications

Species Reactivity

Avian, Dog, Human, Marsupial, Mouse, Non-human primate, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

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View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

HRP HRP HRP

Form

Liquid

Concentration

0.82 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice

RRID

AB_11153794

Product Specific Information

In Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form).

Additional bands may be seen at lower molecular weights.

Target Information

FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.