Thermo Fisher Scientific LOX-1 Monoclonal Antibody (23C11), Biotin
LOX-1 단백질을 인식하는 Biotin 결합 단클론 항체(23C11)로, 인간 시료에 반응합니다. IHC, ICC/IF, 유세포분석, 기능적 분석에 적합하며, 단백질 G로 정제되어 높은 순도를 제공합니다. 항체는 4°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Functional Assay (Functional) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23C11 |
| Immunogen | Fusion protein of extracellular domain (aa 71–273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage buffer | PBS with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_3093172 |
Additional Formats
Product Specific Information
Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation.
In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.
Target Information
LOX-1 (lectin-like oxidized LDL receptor-1) is a 40–50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets, and smooth muscle cells.
LOX-1 binds to oxidized low-density lipoprotein (oxLDL), hypochlorite-modified high-density lipoprotein (HDL), aged/apoptotic cells, activated platelets, and bacteria, reflecting its versatile physiological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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