Thermo Fisher Scientific LOX-1 Monoclonal Antibody (23C11), FITC
인간 LOX-1에 특이적인 Mouse IgG1 단클론 항체로 FITC 형광 표지. IHC, ICC/IF, Flow Cytometry, Functional Assay 등 다양한 응용 가능. LOX-1 중화 및 Hsp70 결합 억제 기능 보유. 항암 면역 연구에 활용 가능.
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Thermo Fisher Scientific LOX-1 Monoclonal Antibody (23C11), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Functional Assay (Functional) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23C11 |
| Immunogen | Fusion protein of extracellular domain (aa 71–273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093275 |
Additional Formats
- Unconjugated: MA5-49083
- Biotin: MA5-49084
- Request custom conjugation available
Product Specific Information
Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.
Target Information
LOX-1 (lectin-like oxidized LDL receptor-1) is a 40–50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets, and smooth muscle cells.
It binds to oxidized LDL, hypochlorite-modified HDL, aged/apoptotic cells, activated platelets, and bacteria, reflecting its versatile physiological functions.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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