Thermo Fisher Scientific CYR61 Polyclonal Antibody
Rabbit polyclonal antibody recognizing CYR61 protein for WB and IHC applications. Validated for mouse samples. Supplied in liquid form, 0.5 mg/mL concentration. Suitable for angiogenesis and tumor progression research.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–4 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding amino acid 166 of mouse Cyr61 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2276978 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor-inducible immediate-early gene that associates with the extracellular matrix and connective tissue. It belongs to the CCN protein family, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog Fisp12.
As an angiogenic inducer, CYR61 binds to the integrin αvβ3 receptor, stimulating cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Expression of CYR61 increases during vessel growth, wound healing, and chondrocyte differentiation. It is also found in various tumors, where it promotes tumor growth and serves as a marker of tumor progression.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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