Thermo Fisher Scientific TAOK1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 4.4 µg/mL

Product Specifications

Product Specific Information

PA1-24577 detects Serine/threonine kinase TAO kinase 1 in Human samples.

Target Information

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).
The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway.
A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK), is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay.
TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response, and regulation of cytoskeleton stability.
It phosphorylates MAP2K3, MAP2K6, and MARK2, acting as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of upstream MAP2K3 and MAP2K6 kinases.
TAOK1 is also involved in G-protein coupled receptor signaling to p38/MAPK14.
In response to DNA damage, TAOK1 participates in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade via phosphorylation of MAP2K3 and MAP2K6.
Additionally, it serves as a regulator of cytoskeleton stability and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.