Thermo Fisher Scientific Phospho-TERT (Tyr707) Polyclonal Antibody
인간 TERT Tyr707 인산화 부위를 인식하는 Rabbit Polyclonal 항체. ICC/IF, Dot blot, Flow Cytometry에 적합. 단백질 A 및 항원 친화 크로마토그래피로 정제. PBS(pH 7.4) 버퍼, 0.09% sodium azide 함유. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | - | View 1 publication |
| Dot blot (DB) | 1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y707 of human TERT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2201586 |
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by the TERT gene, and an RNA component serving as a template for telomere repeat synthesis. Telomerase expression is repressed in most postnatal somatic cells, leading to telomere shortening and cellular senescence. Deregulation of telomerase may contribute to oncogenesis. In mice, telomerase has been implicated in chromosomal repair via de novo synthesis of telomere repeats at double-stranded breaks. Alternative splicing of TERT produces multiple isoforms, some of which remain incompletely characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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