Thermo Fisher Scientific Phospho-TBK1 (Ser172) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse and Xenopus based on sequence homology.

Target Information

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.
NF-KB mediates the expression of a wide variety of genes in response to extracellular stimuli and is associated with IKB proteins in the cytoplasm, which inhibit NF-KB activity.
Phosphorylation of I-KB by the IKK complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK.
A novel IKK-related kinase, TBK1 (also known as TANK-binding kinase 1, NAK, or T2K), activates IKK beta through direct phosphorylation. TBK1 is activated by growth factors and PMA, mediating IKK and NF-kB activation in response to these stimuli, and functions upstream of NIK and the IKK complex.
TBK1 is also critical in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.